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Cotinine is the primary metabolite of nicotine
However, e-cigarettes can also cause nicotine dependence, so users may need treatment for nicotine dependence similar to that for tobacco users
People tend to dismiss effects that are perceived to lie in the distant future, he wrote, going on to quote author (and legendary drinker) Kingsley Amis observation that no pleasure is worth giving up for the sake of two more years in a geriatrichome. But a pleasure might be worth giving up, Spiegelhalter suggested, if people did it for the sake of the time they stood to lose every single day
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